Patent abstract
The invention relates to a solution comprising: a heteropolyacid and a lanthanide salt in a solvent consisting of a water/organic solvent mixture or an organic solvent. Optionally, the solution may also include an organic or inorganic buffer having a pH in the range of 4-6 or a strong base or acid. Also within the scope of the present invention is a use of said solution and any reaction products between its components as a contrastant for biological samples and a method of preparing biological samples, using said solution in at least one step, for analysis by both correlative microscopy (CLEM) and electron microscopy (EM).
Owners
Scuola Normale Superiore di PISA, Fondazione Istituto Italiano di Tecnologia (I.I.T.)
Inventors
Valentina Cappello, Mauro GEMMI, GIOVANNI SIGNORE, Melissa SANTI, ALDO MOSCARDINI, Sebastiano DI PIETRO
Priority question
Deposit number: IT20190001117
Deposit date: 25/01/2019
Patent family
| Deposit number |
Deposit date |
Title |
Deposit country |
| WO2020IB50555 |
24-01-2020 |
CONTRAST SOLUTION FOR THE CHARACTERISATION OF BIOLOGICAL SAMPLES BY ELECTRON OR CORRELATIVE MICROSCOPY |
Mondiale |
| CN20208010944 |
24-01-2020 |
用于由电子显微术或关联显微术表征生物样品的造影溶液 |
Cina |
| EP20200704771 |
24-01-2020 |
CONTRAST SOLUTION FOR THE CHARACTERISATION OF BIOLOGICAL SAMPLES BY ELECTRON OR CORRELATIVE MICROSCOPY |
Europeo |
| US202017425699 |
24-01-2020 |
CONTRAST SOLUTION FOR THE CHARACTERISATION OF BIOLOGICAL SAMPLES BY ELECTRON OR CORRELATIVE MICROSCOPY |
Stati Uniti |
Thematic Area
Healthcare and Biomedical
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