Patent abstract
The present invention concerns the process of preparing multicomponent lipid nanoparticles (LNPs) with high cellular futurogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also concerns the nanoparticles thus obtained. In particular, the lipid nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio between them to be administered both subcutaneously (intradermal or intramuscular) and systemically with fewer side effects compared to the lipid nanoparticles known in the art.
Owners
Scuola Normale Superiore di PISA, Università degli Studi di ROMA La Sapienza, Università degli Studi di CAMERINO
Inventors
Francesco CARDARELLI, Giulio CARACCIOLO, Daniela POZZI, Erica QUAGLIARINI, Serena RENZI, Luca DIGIACOMO, Cristina MARCHINI, Augusto AMICI, Junbiao WANG, Lishan CUI
Priority question
Deposit number: IT202200016386
Deposit date: 02/08/2022
Patent family
| Deposit number |
Deposit date |
Title |
Deposit country |
| WO2023IB57827 |
02-08-2023 |
MULTICOMPONENT LIPID NANOPARTICLES WITH HIGH CELLULAR FUSOGENICITY FOR THE DELIVERY OF NUCLEIC ACIDS AND RELATED PREPARATION PROCESS |
Mondiale |
Thematic Area
Healthcare and Biomedical
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