Abstract brevetto
The present invention concerns the process of preparing multicomponent lipid nanoparticles (LNPs) with high cellular futurogenicity for the delivery of nucleic acids and in particular for DNA vaccination. The invention also concerns the nanoparticles thus obtained. In particular, the lipid nanoparticles of the invention are obtained by combining cationic lipids and ionizable lipids in a specific ratio between them to be administered both subcutaneously (intradermal or intramuscular) and systemically with fewer side effects compared to the lipid nanoparticles known in the art.
Titolari
Scuola Normale Superiore di PISA, Università degli Studi di ROMA La Sapienza, Università degli Studi di CAMERINO
Inventori
Francesco CARDARELLI, Giulio CARACCIOLO, Daniela POZZI, Erica QUAGLIARINI, Serena RENZI, Luca DIGIACOMO, Cristina MARCHINI, Augusto AMICI, Junbiao WANG, Lishan CUI
Domanda di priorità
Numero deposito: IT202200016386
Data deposito: 02/08/2022
Status
Concesso
Famiglia brevettuale
Numero di deposito |
Data deposito |
Titolo |
Nazione deposito |
WO2023IB57827 |
02-08-2023 |
MULTICOMPONENT LIPID NANOPARTICLES WITH HIGH CELLULAR FUSOGENICITY FOR THE DELIVERY OF NUCLEIC ACIDS AND RELATED PREPARATION PROCESS |
Mondiale |
Area tematica
Sanità e Biomedicale